Phosphatidylserine Dosage: 100mg vs 300mg
You know Phosphatidylserine (PS) is good for your brain. But when you look at the bottle, the dosages vary wildly. Some say 100mg, some say 300mg, and athletes take up to 800mg.
How much do you actually need? The answer depends on your goal: are you maintaining memory, or are you trying to block cortisol?
The Maintenance Dose: 100mg
For general cognitive support and "Anti-Aging," 100mg per day is the standard clinical baseline.
- Goal: Slow down age-related cognitive decline (ARCD).
- Mechanism: This amount is sufficient to slowly replace the PS lost from cell membranes due to aging. It helps maintain membrane fluidity and neurotransmitter function over the long term.
- Timeline: Benefits (like better name recall) typically take 3-6 months to manifest at this dose.
The Performance Dose: 200mg - 300mg
If you are dealing with active brain fog, ADHD symptoms, or early memory loss, 100mg might not be enough. You need a "therapeutic" dose.
- Goal: Improve focus, reduce ADHD symptoms, and improve short-term memory.
- Mechanism: Higher levels of PS are needed to actively repair damaged membranes and improve signal transduction speed in the prefrontal cortex.
- Timeline: Benefits are often felt within 2-4 weeks.
The Cortisol-Blocking Dose: 300mg - 800mg
This is for the stressed-out executive or the high-performance athlete. To actively blunt the cortisol response to stress, studies show you need higher amounts.
Clinical trials involving athletes (runners and golfers) typically use doses starting at 300mg and going up to 800mg. This high concentration is required to signal the pituitary gland to stop producing ACTH (the hormone that triggers cortisol). If you are taking PS specifically to stop the "3 AM wake up" or reduce exercise stress, you likely need at least 300mg.
Why FOG OFF Uses 200mg
We formulated FOG OFF with 200mg of Phosphatidylserine. Why this specific number?
It is the "Goldilocks Dose." It is significantly more potent than the basic 100mg maintenance dose, making it effective for active focus and memory issues. It is also high enough to begin modulating cortisol for most people, without the expense or potential stomach upset of taking 800mg pills.
Summary
100mg keeps the lights on. 300mg+ stops the stress. 200mg is the perfect balance for daily cognitive performance and stress management.
FOG OFF is your optimized daily dose.
Frequently Asked Questions
A: PS is generally very safe. Doses up to 800mg have been used in studies without adverse effects. However, extremely high doses may cause stomach upset or insomnia in sensitive individuals.
A: Yes. If you are taking high doses (e.g., 600mg), splitting it into 3 doses of 200mg throughout the day maintains stable blood levels.
A: Yes. If you are facing a major deadline or exam, taking 2 servings (400mg total PS) can provide extra cortisol-blunting support.
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